Faculty and Staff

Haishi Cao, Ph.D.

Haishi Cao, Ph.D.

Associate Professor and Don Fox Chair
Bruner Hall , 411D
(308) 865-8105

Ph.D., Organic Chemistry, New Mexico Institute of Mining and Technology, 2004
M.Sc., Biochemistry, Jilin University (China), 1999
B.Sc., Biochemistry, Jilin University (China), 1995

Areas of Interest
Fluorescence sensing, Chemosensor, Molecular recognition and Detection of toxic ions and biological molecules.

Faculty Appointments
2012-Present, Associate Professor
2007-2012, Assistant Professor, Department of Chemistry

ǂ denotes undergraduate author in UNK
*denotes corresponding author

25. Song, Q. ǂ; Bamesberger, A. ǂ; Yang, L. ǂ; Houtwed, H. ǂ; Cao, H.*, Excimer-monomer switch: a reaction-based approach for selective detection of fluoride, Analyst, 2014, DOI:10.1039/C4AN00522H 

toc 25

24. Bamesbergera, A.ǂ; Schwartza, C.; Song, Q. ǂ; Han, W.; Wang, Z.; Cao, H.*, Rational design of a rapid fluorescent approach for detection of inorganic fluoride in MeCN/H2O: a new fluorescence switch based aryl-1,8-naphthalimide, New. J. Chem., 2014, 38, 884-888.  


  23.Yang, L. ǂ; Song, Q. ǂ; Damit-Og, K. ǂ; Cao, H.*, Synthesis and spectral investigation of a turn-on fluorescence sensor with high affinity to Cu2+Sensor Actuat B-Chem., 2013, 176, 181-185.

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22. Wang, J. ǂ; Yang, L. ǂ; Hou, C. ǂ; Cao, H.*, A new N-imidazol-1,8-naphthalimide based fluorescence sensor for fluoride detection,  Org. Biomol. Chem., 2012, 10, 6271-6274.


21. Hou, C. ǂ; Urbanec, A.M. ǂ; and Cao, H.*, A rapid Hg2+ sensor based on aza-15-crown-5 ether functionalized 1,8-naphthalimide Tetrahedron Lett., 2011, 4903-4905. 


20. Hou, C. ǂ; Xiong, Y.; Fu, N.; Jacquot, C.C. ǂ; Squier, T.C.; and Cao, H.*, Turn-On ratiometric fluorescent sensor toward Pb(II) detection  Tetrahedron Lett.2011, 2692-2696.


19. Yang, Y. ǂ; Gou, X.; Blecha, J. ǂ; Cao, H.*, A highly selective pyrene based fluorescent sensor toward Hg2+ detection  Tetrahedron Lett., 2010, 3422-3425.


18. Gou, X.; Cao, H.*, Undergraduate chemistry education in Chinese universities J. Chem. Educ.2010, 87 (6) 575-577.

Publication Prior to UNK
17. Cao, H.; Xiong, Y.; Wang, T.; Squier, T.C.; Mayer, M. U., A red cy3-based biarsenical fluorescent probe targeted to a complementary binding peptide J. Am. Chem. Soc., 2007, 129, 8672-8673, Highlighted in Nature, 2007, 448, July 5th, 4

16. Chen, B.; Cao, H.; Yan, P; Mayer, M.U.; Squier, T.C., Identification of an orthogonal peptide binding motif for biarsenical multiuse affinity probes Bioconjugate Chem., 2007, 1269-1265.

15. Cao, H.; Chen, B.; Squier, T.C.; Mayer, M.U., CrAsH: A biarsenical multi-use affinity probe with low non-specific fluorescence Chem. Commun. 2006, 2601-2603.

14. Cao, H.; Chang, V.; Hernandez, R.; Heagy, M.D., Matrix library screening of substituted N-Aryl-1,8-naphthalimides reveals new dual fluorescent dyes and unusually bright pyridine derivatives J. Org .Chem., 2005, 70, 4929-4934.

13. Cao, H.; McGill, T.; Heagy, M.D., Sustituent effects on monoboronic acid sensors for saccharides based on N-phenyl-1,8-naphthalenedicarboximides J. Org. Chem., 2004, 2959-2966.

12. Cao, H.; Heagy, M.D., Fluorescent chemosensors for carbohydrates: A decade’s worth of bright spies for saccharides in review J. Fluorescence, 2004, 569-584.

11. Geddes, CD.; Cao, H.; Gryczynski, I.; Gryczynski, Z.; Fang, J.; Lakowicz, J.R., Metalenhanced fluorescence (MEF) due to silver solloids on a planar surface: potential applications of indocyanine green to in vivo imaging J. Phys. Chem. A , 2003, 3443-3449.

10. Geddes, C.D.; Cao, H.; Lakowicz, J.R., Enhanced photostability of ICG in close proximity  to gold colloids Spectrochimica Acta A, 2003, 2611-2617.

9. Sun, H.; Cao, H.; Luo, G., Preparation and property of palmitoyl modified SOD Chinese J. Bioprocess. Eng., 2003, 47-51.

8. Cao, H.; Diaz, D.I.; DiCesare, N.; Lakowicz, J.R., Heagy, M.D., Monoboronic acid sensor that displays anomalous fluorescence sensitivity to glucose Org. Lett., 2002, 1503-1505.

7. Liang, F.; Wu, Y.; Cao, H.; Guo, H.; Liu, L.; Sun, H.; Chen, W.; Liu, S., Chemical modification of human plasminogen Chem. J. Chinese Univ. 2001, 22(4) 577-580.

6. Xu, J.; Ma, J.; Xu, H.; Ma, Z.; Kong, X.; Cao, H.; Guo, H.; Liu, L., Separation and  purification of pullulan  and its function to protect polyphenol tea in green tea Acta Scientiarum Naturalium Universitatis Jilinensis, 2001, 88-90.

5. Cao, H.; Sun, H.; Liang, F.; Guo, H.; Liu, L., Purification and identification of pulullan Chem. J. Chinese Univ. 1999, 20(12) 78-84.

4. Yang, F.; Guo, H.; Xu, H.; Cao, H.; Liu, L., Biochemical analyses of the thrombin-like enzyme product from the venom of agkistrodon halys ussuriensis emilianov Acta Scientiarum Naturalium Universitatis Jilinensis, 1999, (2) 79-82.

3. Yang, F.; Xu, H.; Guo, H;, Cao, H.; Liu, L., Purification and quality control of thrombin-Like enzyme from venom of agkistrodon halys ussuriensis emilianov Chin. J. Biologicals, 1999, (12) 100-102.

2. Qiu, A.; Sun, H.; Zhong, H.; Liu, S.; Zhao, C.; Wu, Y.; Cao, H.; Liu, L., Purification and properties of human plasminogen Acta Scientiarum Naturalium Universitatis Jilinensis, 1998, (3) 79-81.

1. Zhao, H.; Li, C.; Xue, Y.; Zhang, L.; Cao, H.; Guo, H.; Liu, L., Mutation and screening of  high production strain of pullulan Acta Scientiarum Naturalium Universitatis Jilinensis, 1998, (3) 75-78.