Dr. Yipeng Sui's headshot

Dr. Yipeng Sui

Assistant Professor
suiy@unk.edu
(308) 865-8000
BHS 201E
Department of Biology
Research focus areas: Biomedical Research

Areas of Expertise

  • Biology
  • Biomedicine

Area of Interest

  • Cardiovascular disease
  • Obesity-related metabolic disorder

Degrees

  • B.S. (2004) - Shaanxi Normal University, China
  • Ph.D. (2009) - Shandong University, China

Professional Affiliations

  • American Heart Association
  • Entomology Society of America

Dissertation

Sui, Y.  2009.  Characterization and influences of classical insect hormones on the expression profiles of proteases and lipase from the cotton bollworm.  Ph.D. Dissertation, Shandong University. 

Publications

  • Brown, C., Kariuki, W., Zhong, H.A., Kippes, A., and Sui, Y.  2024.  Cannabidiol promotes intestinal cholesterol uptake mediated by Pregnane X receptor.  Front Endocrinol (Lausanne) 15:1398462. PubMed Central PMCID: PMC11217338.
  • Sui, Y., Meng, Z., Chen, J., Liu, J., Hernandez, R., Gonzales, M.B., Gwag, T., Morris, A.J., and Zhou, C.  2021.  Effects of dicyclohexyl phthalate exposure on pxr activation and lipid homeostasis in mice.  Environmental Health Perspectives 129(12)  doi.org/10.1289/EHP9262
  • Sui, Y., Meng, Z., Park, S.H., Lu, W., Livelo, C., Chen, Q., Zhou, T., and Zhou, C.  2020.  Myeloid-specific deficiency of pregnane X receptor decreases atherosclerosis in LDL receptor-deficient mice.  J Lipid Res doi:10.1194/jlr.RA119000122.  PMID: 32170024.
  • Hoffman, J., Petriello, M., Morris, A., Mottaleb, M., Sui, Y., Zhou, C., Deng, P., Wang, C., and Hennig, B.  2020.  Prebiotic inulin consumption reduces dioxin-like PCB 126-mediated hepatotoxicity and gut dysbiosis in hyperlipidemic Ldlr deficient mice.  Environ Pollut  doi:10.1016/j.envpol.2020.114183.  PMID: 32105967.
  • Meng, Z., Gwag, T., Sui, Y., Park, S.H., Zhou, X., and Zhou, C.  2019.  The atypical antipsychotic quetiapine induces hyperlipidemia by activating intestinal PXR signaling.  JCI Insight 4(3). pii: 125657.  PMID: 30728326.
  • Gwag, T., Meng, Z., Sui, Y., Helsley, R.N., Park, S.H., Greenberg, R.N., and Zhou, C.  2019.  Non-nucleoside reverse transcriptase inhibitor efavirenz activates PXR to induce hypercholesterolemia and hepatic steatosis in mice.  J Hepatology pii: S0168-8278(19)30029-7.  PMID: 30677459.
  • Sui, Y., Park, S.H., Wang, F., and Zhou, C.  2018.  Perinatal bisphenol A exposure increases atherosclerosis in adult male PXR-humanized mice.  Endocrinology 159: 1595-1608.  PMID: 29425287.
  • Sui, Y., Liu, Z., Park, S.H., Thatcher, S.E., Zhu, B., Fernandez, J.P., Molina, H., Kern, P.A., and Zhou, C.  2018.  IKKβ is a β-catenin kinase that regulates mesenchymal stem cell differentiation.  JCI Insight 3: e96660.  PMID: 29367460.
  • Wang, F., Liu, Z., Park, S.H., Gwag, T., Lu, W., Ma, M., Sui, Y., and Zhou, C.  2018.  Myeloid β-catenin deficiency exacerbates atherosclerosis in low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 38: doi: 10.1161/ ATVBAHA.118.311059.  PMID: 29724817.
  • Helsley, R.N., Sui, Y., Park, S-H., Liu, Z., Lee, R.G., Zhu, B., Kern, P.A., and Zhou, C.  2016.  Targeting IκB kinase β in adipocyte lineage cells for treatment of obesity and metabolic dysfunctions.  Stem Cells 34:1883-1895.  PMID: 26991836.
  • Park, S-H., Liu, Z., Sui, Y., Helsley, R.N., Powell, D.K., Zhu, B., Kern, P.A., and Zhou, C.  2016.  IKKβ is essential for adipocyte survival and adaptive adipose remodeling in obesity.  Diabetes 65:1616-29.  PMID: 26993069.
  • Sui, Y.*, Helsley, R.N.*, Park, S.H., Song, X., Liu, Z., and Zhou, C.  2015.  Intestinal pregnane X receptor links xenobiotic exposure and hypercholesterolemia.  Mol Endocrinol 29:765-776.  (*Co-first authors).  PMID: 25811240.
  • Sui, Y., Park, S.H., Helsley, R.N., Sunkara, M., Gonzalez, F.J., Morris, A.J., and Zhou, C.  2014.  Bisphenol A increases atherosclerosis in pregnane X receptor-humanized ApoE deficient mice.  J Am Heart Assoc 3: e000492.  PMID: 24755147.
  • Sui, Y., Park, S.H., Xu, J., Monette, S., Helsley, R.N., Han, S.S., and Zhou, C.  2014.  IKKβ links vascular inflammation to obesity and atherosclerosis.  J Exp Med 211:869-886.  PMID: 24799533.
  • Cui, Y., Sui, Y., Xu, J., Zhu, F., and Palli, S.R.  2014.  Juvenile hormone regulates Aedes aegypti Krüppel homolog 1 through a conserved E box motif.  Insect Biochem Mol Biol 52:23-32.  PMID: 24931431.
  • Helsley, R.N.*, Sui, Y.*, Ai, N., Park, S.H., Welsh, W.J., and Zhou, C.  2013.  Pregnane X receptor mediates dyslipidemia induced by the HIV protease inhibitor amprenavir in mice.  Mol Pharmacol 83:1190-9.  (*Co-first authors).  PMID: 23519392.
  • Sui, Y., Ai, N., Park, S.H., Rios-Pilier, J., Perkins, J.T., Welsh, W.J., and Zhou, C.  2012.  Bisphenol A and its analogues activate human pregnane X receptor.  Environ Health Perspect 120:399-405.  PMID: 22214767.
  • Park, S.H., Sui, Y., Gizard, F., Xu, J., Rios-Pilier, J., Helsley, R.N., Han, S.S., and Zhou, C.  2012.  Myeloidspecific IκB kinase β deficiency decreases atherosclerosis in low-density lipoprotein receptor-deficient mice.  Arterioscler Thromb Vasc Biol 32:2869-2876.  PMID: 23023371.
  • Sui, Y., Xu, J., Rios-Pilier, J., and Zhou, C.  2011.  Deficiency of PXR decreases atherosclerosis in apoE deficient mice.  J Lipid Res 52:1652-1659.  PMID: 21685500.
  • Zhang, Z., Xu, J., Sheng, Z., Sui, Y., and Palli, S.R.  2011.  Steroid receptor co-activator is required for juvenile hormone signal transduction through a bHLH-PAS transcription factor, methoprene tolerant.  J Biol Chem 286:8437-47.  PMID: 21190938.
  • Sui, Y., Wang, J., and Zhao, X.  2009.  The impacts of classical insect hormones on the expression profiles of a new digestive trypsin-like protease (TLP) from the cotton bollworm, Helicoverpa armigera.  Insect Mol Biol 18:443–452.  PMID: 19469806.
  • Sui, Y., Liu, X., Chai, L., Wang, J., and Zhao, X.  2009.  Characterization and influences of classical insect hormones on the expression profiles of a molting carboxypeptidase A from the cotton bollworm (Helicoverpa armigera).  Insect Mol Biol 18:353–363.  PMID: 19523067.
  • Liu, Y., Sui, Y., Wang, J., and Zhao, X.  2009.  Characterization of the trypsin-like protease (Ha-TLP2) constitutively expressed in the integument of the cotton bollworm, Helicoverpa armigera.  Arch Insect Biochem Physiol 72:74-87.  PMID: 19557747.
  • Sui, Y., Wang, J., and Zhao, X.  2008.  Effects of classical insect hormones on the expression profiles of a lipase gene from the cotton bollworm (Helicoverpa armigera).  Insect Mol Biol 17:523–529. PMID:18828838.

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