HAISHI CAO
Education and Research
Pacific Northwest National Laboratory, Richland WA
Postdoctoral Fellow with Thomas C. Squier and M. Uljana Mayer, Nov. 2004-2007
● Synthesis of fluorescent bisarsenical probes for protein labeling
● Cell imaging
University of Maryland at Baltimore, Baltimore, MD
Visiting Scientist in Dr. Joseph R. Lakowicz group, 2002 summer
● Metal-enhanced fluorescence
New Mexico Institute of Mining & Technology, Socorro, NM
Graduate research with Michael D. Heagy, Aug. 1999-Oct. 2004
Ph.D, Organic Chemistry and M.Sc. Organic Chemistry
● Design of fluorescent chemosensors for saccharide sensing
● Investigation of substituent effects on N-aryl-1,8-naphthalimides for dual fluorescence
Jilin University, Changchun, CHINA
Graduate research with Lanying Liu, Aug. 1996-July 1999
M.Sc. Biochemistry, July 1999
● Purification and characterization of Pullulan polysaccharide
● Modification of enzymes
Jilin University, Changchun, CHINA
Undergraduate study with Guimin Luo, Aug. 1991-July 1995
B.Sc. Biochemistry, July 1995
● Chemical modification of superoxide dismutase
Honors and Awards
2004 - 2007 Post-doctoral Systems Biology Fellowship, Pacific Northwest National Laboratory
2001 American Chemical Society poster award at central New Mexico section
1997 - 1999 First Class Outstanding Graduate Student Fellowship, Jilin University
Professional Affiliations
American Chemical Society
The Society of Fluorescence
The Protein Society
Publications
1. Cao, H.; Xiong, Y.; Wang, T.; Squier, T. C.; Mayer, M. U., “A Red Cy3-Based Biarsenical Fluorescent Probe
Targeted to a Complementary Binding Peptide” J. Am. Chem. Soc., 2007, 8672-8673
Highlighted in Nature, 2007, Vol448, July 5th, 4
2. Chen, B.; Cao, H.; Yan, P; Mayer, M. U.; Squier, T. C.; “Identification of an Orthogonal Peptide Binding
Motif for Biarsenical Multiuse Affinity Probes” Bioconjugate Chem., 2007, 1259-1265
- Cao, H.; Chen, B.; Squier, T. C.; Mayer, M. U., “ CrAsH: A Biarsenical Multi-use Affinity Probe with
Low Non-specific Fluorescence” Chem. Commun.,2006, 2601 - 2603
4. Cao, H.; Chang, V.; Hernandez, R.; Heagy, MD., “Matrix library screening of substituted N-Aryl-1,8-
naphthalimides reveals new dual fluorescent dyes and unusually bright pyridine derivatives” J. Org.
Chem., 2005, 70, 4929-4934
- Cao, H.; McGill, T.; Heagy, MD., “Sustituent effects on monoboronic acid sensors for saccharides based
on N-phenyl-1,8-naphthalenedicarboximides”J. Org. Chem., 2004, 2959-2966.
6. Cao, H.; Heagy, MD., “Fluorescent chemosensors for carbohydrates: A decade’s worth of bright spies for
saccharides in review”J. Fluorescence, 2004, 569-584.
7. Geddes, CD.; Cao, H.; Gryczynski, I.; Gryczynski, Z.; Fang, J.; Lakowicz, JR., “Metal-enhanced
fluorescence (MEF) due to silver solloids on a planar surface: potential applications of indocyanine
green to in vivo imaging”J. Phys. Chem. A, 2003, 3443-3449
- Geddes, CD.; Cao, H.; Lakowicz, JR., “Enhanced photostability of ICG in close proximity to gold colloids”
Spectrochimica Acta A, 2003, 2611-2617
9. Sun, H.; Cao, H.; Luo, G.," Preparation and property of palmitoyl Modified DOS" Chinese J. Bioprocess.
Eng., 2003, 47-51
10. Cao, H.; Diaz, DI.; DiCesare, N.; Lakowicz, JR., Heagy, MD.,“Monoboronic acid sensor that displays
anomalous fluorescence sensitivity to glucose”Org.Lett., 2002, 1503-1505
11. Liang, F.; Wu, Y.; Cao, H.; Guo, H.; Liu, L.; Sun, H.; Chen, W.; Liu, S., “Chemical modification of human
plasminogen” Chem. J. Chinese Univ., 2001, 22(4), 577-580
12. Cao, H.; Sun, H.; Liang, F.; Guo, H.; Liu, L., "Purification and Identification of Pululian". Chem. J. Chinese
Univ., 1999, 20(12), 78-84.
Patent
Biarsenical Probes for Two-color Fluorescence Imaging. Pacific Northwest National Laboratory,
Patent in preparation.