Michael Moxley, Ph.D.

Assistant Professor, Biochemistry

Office: BHS 409 A   |    Phone: (308) 865-8262   |    Email: moxleyma@unk.edu

Michael A Moxley, Ph.D.

Biography

Education

Postdoctoral Fellow, University of Michigan – Ann Arbor, October 2014 – June 2017

Postdoctoral Fellow, Medical College of Wisconsin - Milwaukee, June 2012 –  October 2014

Ph.D., Biochemistry, University of Nebraska Lincoln, 2012

B.S., Biochemistry, University of Nebraska Lincoln, 2006

Faculty Appointments

2017-present, Assistant Professor of Biochemistry, Department of Chemistry, University of Nebraska Kearney

Research Interests

My research interests are focused on interfacing enzymology and systems biology in the area of fat and glucose metabolism. Overall, I am interested in combining knowledge of enzyme kinetics and mechanism with knowledge of metabolic pathways to better understand metabolic regulation and control in normal and disease states.


Publications

  • Moxley, M.A., Vinnakota, KC, Beard DA. Systems-level computational modeling explains fuel selection switching in high capacity and low capacity running rats. (Submitted to PLOS Computational Biology, June 2017).

  • Moxley, M.A., Zhang, L., Christgen, S, Tanner, JJ, Becker, DF. Identification of a Conserved Histidine As Being Critical for the Catalytic Mechanism and Functional Switching of the Multifunctional Proline Utilization A Protein. Biochemistry 56: 3078-3088 (2017).

  • Moxley, M.A., Beard DA, Bazil JN. Global Kinetic Analysis of Mammalian E3 Reveals pHdependent NAD+ /NADH Regulation, Physiological Kinetic Reversibility, and Catalytic Optimum. Journal of biological chemistry. 291: 2712-30 (2016).

  • Moxley, M.A., Beard DA, Bazil JN. A pH-dependent Kinetic Mechanism of Dihydrolipoamide Dehydrogenase from Multiple Organisms. Biophysical journal 107: 2993-3007 (2014).

  • Moxley, M.A., Sanyal, N, Krishnan, N, Tanner, JJ, Becker DF. Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1 -pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA). Journal of biological chemistry. 289: 3639-51 (2014).

  • Srivastava D., Ranjan S.K., Moxley M.A., Henzel M.T., Becker D.F., Tanner J.J. The three dimensional structural basis of type II hyperprolinemia. J Mol Biol. 420:176-89. (2012).

  • Moxley, M.A., Becker, DF. Rapid Reaction Kinetics of Proline Dehydrogenase in the Multifunctional Proline Utilization A Protein. Biochemistry 51: 511-520 (2012).

  • Moxley, M.A., Tanner, JJ, Becker, DF. Steady-state kinetic Mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli. Arch Biochem Biophys 516: 113-20 (2011).

  • Becker, DF., Zhu, W. Moxley M.A. Flavin Redox Switching of Protein Functions. Antioxid. Redox Signal 14(6) 1079-91 (2011) (Review).